Ryanodine receptor resolution revolution: Implications for InsP3 receptors?
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چکیده
منابع مشابه
Ryanodine Receptors in Autophagy: Implications for Neurodegenerative Diseases?
Citation: Vervliet T (2018) Ryanodine Receptors in Autophagy: Implications for Neurodegenerative Diseases? Front. Cell. Neurosci. 12:89. doi: 10.3389/fncel.2018.00089 Intracellular Ca2+ signaling is important in the regulation of several cellular processes including autophagy. The endoplasmic reticulum (ER) is the main and largest intracellular Ca2+ store. At the ER two protein families of Ca2+...
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In rat portal vein myocytes, Ca2+ signals can be generated by inositol 1,4,5-trisphosphate (InsP3)- and ryanodine-sensitive Ca2+ release channels, which are located on the same intracellular store. Using a laser scanning confocal microscope associated with the patch-clamp technique, we showed that propagated Ca2+ waves evoked by norepinephrine (in the continuous presence of oxodipine) were comp...
متن کاملRyanodine receptors
ISSN: 1933-6950 (Print) 1933-6969 (Online) Journal homepage: http://www.tandfonline.com/loi/kchl20 Ryanodine receptors Mounia Chami & Frédéric Checler To cite this article: Mounia Chami & Frédéric Checler (2014) Ryanodine receptors, Channels, 8:3, 168-168, DOI: 10.4161/chan.29000 To link to this article: http://dx.doi.org/10.4161/chan.29000 Copyright © 2014 Landes Bioscience Published online: 2...
متن کاملSarcolemma agonist-induced interactions between InsP3 and ryanodine receptors in Ca2+ oscillations and waves in smooth muscle.
Smooth muscle cells respond to InsP(3)-generating (sarcolemma-acting) neurotransmitters and hormones by releasing Ca(2+) from the internal store. However, the release of Ca(2+) does not occur uniformly throughout the cytoplasm but often into a localized area before being transmitted to other regions of the cell in the form of Ca(2+) waves and oscillations to actively spread information within a...
متن کاملRyanodine Receptors: Structure
Ryanodine receptors (RyRs) are huge ion channels that are responsible for the release of Ca2 from the sarco/endoplasmic reticulum. RyRs form homotetramers with a mushroom-like shape, consisting of a large cytoplasmic head and transmembrane stalk. Ca2 is a major physiological ligand that triggers opening of RyRs, but a plethora of modulatory proteins and small molecules in the cytoplasm and sarc...
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ژورنال
عنوان ژورنال: Cell Calcium
سال: 2017
ISSN: 0143-4160
DOI: 10.1016/j.ceca.2016.11.002